Zebrafish made to grow pre-hands instead of fins

PERHAPS the little fish embryo shown here is dancing a jig because it has just discovered that it has legs instead of fins. Fossils show that limbs evolved from fins, but a new study shows how it may have happened, live in the lab.

Fernando Casares of the Spanish National Research Council and his colleagues injected zebrafish with the hoxd13 gene from a mouse. The protein that the gene codes for controls the development of autopods, a precursor to hands, feet and paws.

Zebrafish naturally carry hoxd13 but produce less of the protein than tetrapods - all four-limbed vertebrates and birds - do. Casares and his colleagues hoped that by injecting extra copies of the gene into the zebrafish embryos, some of their cells would make more of the protein.

One full day later, all of those fish whose cells had taken up the gene began to develop autopods instead of fins. They carried on growing for four days but then died (Cell, DOI: 10.1016/j.devcel.2012.10.015).

"Of course, we haven't been able to grow hands," says Casares. He speculates that hundreds of millions of years ago, the ancestors of tetrapods began expressing more hoxd13 for some reason and that this could have allowed them to evolve autopods.

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Resolution of stalled upgrading works at Rivervale Plaza one key priority: DPM

SINGAPORE: Deputy Prime Minister Teo Chee Hean has said that one of the priorities he wants to tackle for Punggol East residents is the resolution of upgrading works at Rivervale Plaza.

Works there have been delayed because the contractor has gone bust.

Mr Teo, who is also the anchor minister for Pasir Ris-Punggol GRC, was speaking to reporters on the sidelines of a community event on Sunday.

The Deepavali celebration is the second community event Mr Teo attended over the weekend, following the resignation of Punggol East MP Michael Palmer over an extramarital affair.

Mr Teo noted that one of the concerns of residents is the upgrading works at Rivervale.

He said his team of MPs will continue discussions, started by Mr Palmer, with the Housing and Development Board, residents and shop owners, to resolve the problem.

Mayor Teo Ser Luck has been appointed caretaker MP for Punggol East.

Mr Teo Chee Hean said: "We've always looked after the residents (of Punggol East) as a larger Pasir Ris-Punggol family. So I know quite a lot of the grassroots leaders here. I've been here many times also, with Mr Teo Ser Luck as well. So we will continue looking after residents."

DPM Teo has said he will attend the ward's Meet-the-People session on Monday night.

- CNA/ir

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Google will alter search to end FTC antitrust inquiry, says report

The Federal Trade Commission may bring its two-year antitrust investigation of Google to a close by allowing the company to make voluntary changes to its search business, according to a report.

The search giant is said to be readying an announcement about changes to its use of "snippets," bits of text culled from sites such as Yelp and TripAdvisor and displayed in search results, Politico reports, citing unnamed sources. Yelp and others had charged Google with using their content without permission.

Google will also makes tweaks that will allow for easier porting of search-ad campaigns from Google to rival search services, Politico's sources said.

Politico suggested on Tuesday that the FTC may leave the search-related case to the European Commission, which has mounted an investigation of its own. Reuters reported on Tuesday that some Google competitors, sensing a possible defeat, are taking the case to the Justice Department.

Google and the FTC also look to be close to a settlement in a case involving so-called frand -- or standard essential -- patents owned by Google.

Politico said the FTC declined to comment on today's report about the search tweaks, and it said Google would provide only the following statement: "We continue to work cooperatively with the Federal Trade Commission and are happy to answer any questions they may have."

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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Conn. Victim's Father Remembers 'Loving' Daughter

(Image credit: Emilie Parker Fund/Facebook)

Emilie Parker, the little girl with the blond hair and bright blue eyes, would have been one of the first to comfort her classmates at Sandy Hook Elementary School, had a gunman’s bullets not claimed her life, her father said.

“My daughter Emilie would be one of the first ones to be standing and giving support to all the victims because that’s the kind of kid she is,” her father, Robbie Parker said as he fought back tears, telling the world about his “bright, creative and loving” daughter who was one of the 20 young victims in the Newtown, Conn., shooting.

“She always had something kind to say about anybody,” her father said.  ”We find comfort reflecting on the incredible person Emilie was and how many lives she was able to touch.”

Emilie, 6, was helping teach her younger sisters to read and make things, and she was the little girls would go to for comfort, he said.

“They looked up to her,” Parker said.

READ: Complete List of Sandy Hook Victims

Parker moved his wife and three daughters to Newtown eight months ago after accepting a job as  a physician’s assistant at Danbury Hospital. He said Emilie, his oldest daughter, seemed to have adjusted well to her new school, and he was very happy with the school, too.

“I love the people at the school. I love Emilie’s teacher and the classmates we were able to get to know,” he said.

      (Image Credit: Alex von Kleydorff/AP Photo)

The family dealt with another tragic loss in October when Emilie lost her grandfather in an accident.

“[This] has been a topic that has been discussed in our family in the past couple of  months,” Parker said. “[My daughters ages 3 and 4] seem to get the idea that there’s somebody who they will miss very much.”

Emilie, a budding artist who carried her markers and pencils everywhere, paid tribute to her grandfather by slipping a special card she had drawn into his casket, Parker said.  It was something she frequently did to lift the spirits of others.

“I can’t count the number of times Emilie would find someone feeling sad or frustrated and would make people a card,” Parker said. “She was an exceptional artist.”

The girl who was remembered as “always willing to try new things, other than food” was learning Portuguese from her father, who speaks the language.

(Image Credit: Emilie Parker Fund/Facebook)

On Friday morning, Emilie woke up before her father left for his job and exchanged a few sentences with him in the language.

“She told me good morning and asked how I was doing,” Parker said. “She said she loved me, I gave her a kiss and I was out the door.”

Parker found out about the shooting while on lockdown in Danbury Hospital and found a television for the latest news.

“I didn’t think it was that big of deal at first,” he said. “With the first reports coming in, it didn’t sound like it was going to be as tragic as it was. That’s kind of what it was like for us.”

CLICK HERE for full coverage of the Sandy Hook shooting.

Parker said he knows that God can’t take away free will and would have been unable to stop the Sandy Hook shooting. While gunman Adam Lanza used his free agency to take innocent lives, Parker said he plans to use his in a positive way.

“I’m not mad because I have my  [free] agency to use this event to do whatever I can to make sure my family and my wife and my daughters are taken care [of],” he said. “And if there’s anything I can do to help to anyone at any time at anywhere, I’m free to do that.”

(Image credit: Emilie Parker Fund/Facebook)

Friday night, hours after he learned of his daughter’s death, Parker said he spoke at his church.

“I don’t know how to get through something like this. My wife and I don’t understand how to process all of this,” he said today. “We find strength in our religion and in our faith and in our family. ”

“It’s a horrific tragedy and I want everyone to know our hearts and prayers go out to them. This includes the family of the shooter. I can’t imagine how hard this experience must be for you and I want you to know our family … love and support goes out to you as well.”

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CERN becomes first pure physics voice in UN chorus

Lisa Grossman, physical sciences reporter

(Image: UN Photo/Paulo Filgueiras)

If CERN observes the proceedings of the United Nations, will it change the outcome?

The international particle physics laboratory, based near Geneva, Switzerland, has been granted observer status in the General Assembly of the United Nations, CERN officials announced today. 

The lab joins environmental groups and public health agencies as the first physical sciences research organization in the ranks of UN observers. Observer status grants the right to speak at meetings, participate in procedural votes, and sign and sponsor resolutions, but not to vote on resolutions.

In some ways, CERN's addition seems a natural move - and a long time coming.

The facility was founded in 1954 under the auspices of the United Nations Educational, Scientific and Cultural Organisation (UNESCO). Its initial mission was to provide collaborative projects for researchers from Allied countries and former Axis countries after the second World War.

Arguably the lab's most high-profile project, the Large Hadron Collider, made headlines worldwide this year when it revealed detection of a new particle that appears to be the elusive Higgs boson.

"Through its projects, which bring together scientists from all over the world, CERN also promotes dialogue between nations and has become a model for international cooperation," CERN states in a press release. The lab says it may use its new status with the UN to help shore up scientific education and technological capabilities in developing countries, particularly in Africa.

But just as observing a quantum particle can change its state, can CERN's involvement truly collapse the UN's wavefunction and trigger better global science and technology policies? Only time will tell.

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NEA's new partnership to enhance S'pore's radiological operational readiness

SINGAPORE: National Environment Agency (NEA) and the Danish Emergency Management Agency (DEMA) have signed a Letter of Intent (LOI) on collaboration in nuclear and radiation safety, emergency preparedness and response.

NEA's partnership with DEMA is meant to enhance Singapore's capabilities in radiological operational readiness and incident response.

The partnership will provide a platform for NEA and DEMA to share and exchange knowledge and technical expertise in several areas -- environmental radiation monitoring, risk assessment of surface contamination, and public protection policies and measures.

Staff exchange visits and attachment programmes are also included in the partnership.

Director of NEA's Centre for Radiation Protection and Nuclear Science Mr Ang Kok Kiat and chief advisor of DEMA's Nuclear Division Mr Steen Cordt Hoe signed the LOI at the sidelines of the Fukushima Ministerial Conference on Nuclear Safety held in Koriyama City of Fukushima Prefecture, Japan.

The collaboration with DEMA was first mooted following a multi-agency delegation visit to Denmark led by NEA's chief executive officer, Mr Andrew Tan, in October 2011.

DEMA, a government agency under the Danish Ministry of Defence, is tasked with leading the Danish response to nuclear emergencies abroad for protection of the population and environment.

DEMA's nuclear emergency management capabilities include a nation-wide automatic monitoring system and forecasting of possible radioactive fallout on the basis of current weather data.

- CNA/lp

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Do I really need insurance for my smartphone?

You may have only paid $200 for your latest smartphone, but if you had to replace that device before you are eligible for a subsidy from your carrier it cost your more than $600. Is it worth it to get device insurance?

That's the question I answer this time in Ask Maggie. I also offer some advice to an Apple iPhone fan who wants to know if he should wait for the next iPhone rumored to be out in June or July.

To buy insurance or live dangerously without?

Dear Maggie,
I am getting my son an
iPhone 5 for Christmas. I was wondering if I should also consider getting an insurance policy for the phone. Is it a good idea or a waste of money? Would I need to get Apple Care in addition to an insurance plan? And do you think I should get the insurance from a carrier or through a third party company?

Thanks,
Karen

Dear Karen,
The problem with buying any kind of insurance is that you simply don't know what will happen in the future. If your son's new iPhone is lost, stolen or damaged in the first few months of owning it, then it's a terrific bargain. But if he goes two years with not so much as a scratch on his precious new gadget, it's a waste of money.

Some people would rather save the money they'd spend on the insurance premiums and deductible, and hope nothing bad happens to their gadget. While others would prefer to have the peace of mind that comes with knowing their device can be replaced right away without having to pay full price for a new device.

The first thing you need to figure out is how much insurance will cost you and what it will cover. As you alluded to in your question, there are several options for purchasing smartphone and other gadget insurance. Wireless operators offer insurance plans as do third party companies. There are also extended warranty plans from device makers like Apple or from retailers like Best Buy, that typically cover mechanical defects to the device and may on some occasions cover some accidental damage coverage. But these programs typically do not cover you for a lost or stolen device.

In general, insurance plans will offer more coverage than an extended warranty. Here are a few things that many insurance policies will likely cover:

• Accidental damage (including shattered screens and liquid damage)
• Loss
• Theft or burglary
• Mechanical breakdown or malfunction beyond the manufacturer warranty

Some insurance policies may also cover things like credit monitoring as well as lock, wipe and locate services if your device is lost or stolen.

Every insurance policy will also include a fee or premium. And they all have a deductible. The fees and deductibles often depend on what kind of device you are insuring. Be aware that many policies charge higher premiums and have higher deductibles for the Apple iPhone as compared to other smartphones.

So make sure you double check the policy to see what the fees and deductibles are. Before you sign up for any insurance, you should check the specifics and fine print to see what is and is not covered.

To get you started on your search, here's a little information about a few options.

AT&T and Verizon Wireless offer insurance for the iPhone. But Sprint, which offers an insurance plan for other smartphones, does not offer a policy for the iPhone. T-Mobile, which doesn't offer the iPhone on its network, also does not have a policy that would cover the iPhone.

There are also insurance policies from third party companies you may want to consider. One such company is called ProtectYourBubble.com. It offers insurance for the iPhone as well as other gadgets. This company offers a 10 percent discount for additional policies you have either on other iPhones or on other gadgets.

Here's a quick look at the offers:

AT&T

Premium: $6.99 per month

Deductible: $199

Verizon Wireless

Premium: $9.99 per month

Deductible: $169 for 8GB, 16GB
iPhone 4, 16GB
iPhone 4S and, 8GB, 16GB iPhone 5 and $199 for 32GB iPhone 4 and 32GB, 64GB iPhone 4S and 32GB, 64GB iPhone 5

Protect Your Bubble

Premium: $7.99 per month

Deductible: $120 (Other smartphones have a deductible of $100.)

Which insurance plan is better? As you can see from the information listed above, Verizon has the most expensive insurance plan. Two years of premiums, plus the deductible will set you back $410. AT&T's premiums and deductible are $368 for the iPhone. And Protect Your Bubble's total comes to $312.

Are any of these policies really worth the cost? Again, it's hard to answer this question since it really depends on how likely it is that you'll need the insurance versus how much risk you're willing to live with if you don't get any insurance.

Remember that if you have to replace the device before your son is eligible for a new contract, it will cost you between $649 to $849 to replace his iPhone with a new iPhone 5 depending on the model you select. You may be able to get a used or refurbished iPhone for a bit less, but iPhones hold their value pretty well, so you will likely still end up paying several hundred dollars to get the same device.

Personally, I am a bit of a cheapskate. And I'm willing to take the risk of something happening to my device. I have never had insurance on any of my smartphones. And (knock on wood) I have never had a cracked screen or a device damaged by water or any other liquid. My iPhone 3G was stolen out of my backpack when I was playing in a flag football game a few years ago, but I was eligible for an upgrade from my carrier, so I only ended up paying $200 for a new phone anyway.

That said, I may soon be one of the few people who does not get insurance for my smartphone. According to Stephen Ebbett of Protect Your Bubble, 45 percent of smartphone subscribers have insurance for their devices. And he said that his company is seeing more and more people sign up for coverage.

"Our sales are growing week on week," he said. "We've been very encouraged by people recognizing the value of their smartphone in their lives. It's not just the cash value of their devices, but the fact that they really can't live without their smartphone for a week."

What about Apple Care?

Apple's AppleCare+ program costs $99 and extends the warranty of the iPhone for another year. The plan covers all repair coverage and technical support. And it also covers up to two incidents of accidental damage, each with an additional cost of $49.

While Apple Care+ is considerably less expensive than the insurance plans, you must remember that it is essentially an extended warranty. And it does not cover you if the device is lost or stolen. For iPhone users, this is a particularly important distinction since iPhone thefts are on the rise. The New York City Police Department said earlier this year that iPhone and iPad thefts went up 40 percent between January and the end of September.

Why? Compared to other gadgets, iPhones have high resale values, so they are often a target for thieves.

Do you need Apple Care+ in addition to insurance? The short answer to that question is no. The insurance policy for the phone will likely cover the same types of technical and accidental damage that the Apple Care+ service offers. The only thing you may lose by forgoing Apple Care+ is online and telephone technical support from Apple. But you should still be able to get some tech support from the Genius bar at your local Apple store. And your son's iPhone will be covered under the regular warranty for the first year that he owns it.

I hope this advice was helpful. And good luck! Happy holidays!

Should I wait for the next iPhone?

Dear Maggie,
I am in need of a new phone (currently using Blackberry Bold 9930 from Sprint) and would like to get the new iPhone. Here is the issue - as a guy who likes to have all the latest and greatest tech I'm rather scared to buy the iPhone 5 with all the "iPhone 5S" rumors that just started. I know it is pretty much impossible to stay up to date with every piece of technology (especially phones) . But if I am going to upgrade I would at least like the newest iteration. So what do you think about these rumors? Any chance that these will be true (it seems nearly every Apple rumor comes true these days)? Should I wait until June/July or just go ahead and get the iPhone 5 that is available now? Lots of questions I know, but these are confusing times.

Thanks in advance,
Jordan

Dear Jordan,
As you mentioned in your question, it is almost impossible to stay up to date with every piece of technology. So my recommendation to you is to not even try to play that game. The soonest we'd likely see an iPhone 5S, if it even exists, is June. That's is still half a year away. That's a long time in the fast-paced smartphone market.

Earlier this month, French Web site Nowhereelse.fr spotted alleged pictures of the next iPhone, commonly referred to as the iPhone 5S, on a forum run by iPhone5parts.net.

(Credit:
Screenshot taken by Roger Cheng/CNET)

It sounds like you need a new smartphone now. So I'd recommend that you stop waiting and purchase a phone that you like right now. If a new iPhone comes out in six months, you could always sell it and still make bake a good portion of your money, which you could put toward a new iPhone.

Good luck with your decision.

Ask Maggie is an advice column that answers readers' wireless and broadband questions. The column now appears twice a week on CNET offering readers a double dosage of Ask Maggie's advice. If you have a question, I'd love to hear from you. Please send me an e-mail at maggie dot reardon at cbs dot com. And please put "Ask Maggie" in the subject header. You can also follow me on Facebook on my Ask Maggie page.

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Space Pictures This Week: Frosty Mars, Mini Nile, More

Photograph by Mike Theiss, National Geographic

The aurora borealis, also known as the northern lights, illuminates the Arctic sky in a recent picture by National Geographic photographer Mike Theiss.

A storm chaser by trade, Theiss is in the Arctic Circle on an expedition to photograph auroras, which result from collisions between charged particles released from the sun's atmosphere and gaseous particles in Earth's atmosphere.

After one particularly amazing show, he wrote on YouTube, "The lights were dancing, rolling, and twisting, and at times looked like they were close enough to touch!" (Watch his time-lapse video of the northern lights.)

Published December 14, 2012

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Conn. Shooter Adam Lanza: 'Obviously Not Well'

Adam Lanza of Newtown, Connecticut was a child of the suburbs and a child of divorce who at age 20 still lived with his mother.

This morning he appears to have started his day by shooting his mother Nancy in the face, and then drove her car to nearby Sandy Hook Elementary School, armed with two handguns and a semi-automatic rifle.

There, before turning his gun on himself, he shot and killed 20 children, who President Obama later described as "beautiful little kids" between five and 10 years of age. Six adults were also killed at the school. Nancy Lanza was found dead in her home.

A relative told ABC News that Adam was "obviously not well."

Family friends in Newtown also described the young man as troubled and described Nancy as rigid. "[Adam] was not connected with the other kids," said Barbara Frey, who also said he was "a little bit different ... Kind of repressed."

State and federal authorities believe his mother may have once worked at the elementary school where Adam went on his deadly rampage, although she was not a teacher, according to relatives, perhaps a volunteer.

Nancy and her husband Peter, Adam's father, divorced in 2009. When they first filed for divorce in 2008, a judge ordered that they participate in a "parenting education program."

Peter Lanza, who drove to northern New Jersey to talk to police and the FBI, is a vice president at GE Capital and had been a partner at global accounting giant Ernst & Young.

Adam's older brother Ryan Lanza, 24, has worked at Ernst & Young for four years, apparently following in his father's footsteps and carving out a solid niche in the tax practice. He too was interviewed by the FBI. Neither he nor his father is under any suspicion.

Tragedy at the Elementary School: What Happened in Newtown, Conn. Watch Video

Newtown, Connecticut Shooting: 27 Killed, Gunman Dead Watch Video

"[Ryan] is a tax guy and he is clean as a whistle," a source familiar with his work said.

Police had initially identified Ryan as the killer. Ryan sent out a series of Facebook posts saying it wasn't him and that he was at work all day. Video records as well as card swipes at Ernst & Young verified his statement that he had been at the office.

Two federal sources told ABC News that identification belonging to Ryan Lanza was found at the scene of the mass shooting. They say that identification may have led to the confusion by authorities during the first hours after the shooting. Neither Adam nor Ryan has any known criminal history.

A Sig Sauer handgun and a Glock handgun were used in the slaying and .223 shell casings – a round used in a semi-automatic military-style rifle -- were also found at the scene. Nancy Lanza had numerous weapons registered to her, including a Glock and a Sig Sauer. She also owned a Bushmaster rifle -- a semi-automatic carbine chambered for a .223 caliber round. However, federal authorities cannot confirm that the handguns or the rifle were the weapons recovered at the school.

Numerous relatives of the Lanzas in New Jersey, Connecticut, Massachusetts, as well as multiple friends, are being interviewed by the FBI in an effort to put together a better picture of the gunman and any explanation for today's tragedy.

"I think the most important thing to point out with this kind of individual is that he did not snap this morning and decide to act out violently," said former FBI profiler Mary Ellen O'Toole. "These acts involve planning and thoughtfulness and strategizing in order to put the plan together so what may appear to be snap behavior is not that at all."

With reporting by Pierre Thomas, Jim Avila, Santina Leuci, Aaron Katersky, Matthew Mosk, Jason Ryan and Jay Shaylor

MORE: 27 Dead, Mostly Children, at Connecticut Elementary School Shooting

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